Professor Yamanaka’s team improves the iPS cell technique by identifying the origin of defective cells

Publié le : 28 November 2013

 A team of scientists led by Professor Shinya Yamanaka, the 2012 Nobel Prize Winner for Medicine, has succeeded in unveiling a sequence of three genes routinely present in defective iPS cells. In other words, once the adult cells have been reprogrammed to reach pluripotency, namely the IPS or Induced Pluripotent Stem cells, some fail to differentiate themselves to create such and such a tissue at the risk of degenerating into cancer cells. The team of scientists has essentially discovered that, out of the 40 iPS cells transformed into neural cells, 7 have proved to be defective. By establishing whether or not these genes are present, scientists have differentiated defective iPS cells from other cells upstream, eliminating them from the process and thus enhancing the quality of the developed tissue. This discovery is vital and appears to be extremely promising for regenerative medicine involving the iPS technique.

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