New reprogramming technique for liver cells

Publié le : 28 February 2014

 San Francisco scientists have published their findings in Nature – the weekly international science journal. They announced their discovery of a new method for reprogramming skin cells (fibroblasts) at the pluripotent stem cell stage "towards an intermediate multipotent progenitor cell stage". This will produce functional liver cells (hepatocytes) capable of proliferating.

So far, scientists have succeeded in reprogramming fibroblasts into induced pluripotent stem cells (IPS cells) to subsequently differentiate them from hepatocytes.

This advance brings hope to the millions of people at risk of contracting disease. "Nevertheless, there is still some way to go before we can introduce this technique into clinical practice" because the safety of these cells must be established.

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