New cardiac reconstruction strategy by virtue of iPS cells

Publié le : 9 September 2013

 According to a study published on Tuesday, 13 August, in the Nature Communications journal, a team of scientists at Pittsburgh University (Pennsylvania, United States) has succeeded in creating "functional cardiac tissue in the laboratory" using induced pluripotent stem (iPS) cells derived from reprogrammed adult human skin cells. According to the scientists, "Cells created in this way were used to repopulate a previously decellularized rodent heart".         

"It is still far from making a whole human heart", explained Lei Yang, co-author of the article. "Ways have to be found to make the heart contract strongly enough to pump blood effectively and to rebuild the heart’s electrical conduction system." Nevertheless, "we have discovered a new cell resource […] to ensure the future of cardiac tissue engineering", emphasised the scientist. He hopes that this study will, in future, allow "tissue or, one day, even an entire organ damaged by a heart attack to be replaced."   
According to scientists, "This new strategy of individual cardiac reconstruction could promote studies into foetal heart formation or be used in the pre-clinical testing of new molecules".

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