iPS (induced pluripotent stem) cells: discovery of new genes for programming

Publié le : 20 September 2013

 In its September 2013 issue, the Cell Stem Cell journal revealed that the Regenerative Medicine Centre (RMC) in Barcelona in conjunction with the Salk Institute in California had succeeded in developing "a new process to obtain iPS cells". The team led by Professor Juan Carlos Izpisua "has just shown that at least seven other genes are capable of interacting in the reprogramming” of stem cells. These genes "are present in adult cells and their combined expression" triggers the reprogramming process. In his iPS cell studies, for which he received the Nobel Prize for Medicine in 2012 (Gènéthique press review on October 8th, 2012), Professor S. Yamanaka introduced four genes. Hence, "rather than attempting to ‘reconstruct’ new tissues in vitro from a patient’s adult stem cells", this new discovery uses an organ "self-repair" mechanism through in-vivo programming.

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