On 18 September 2013, the Nature journal published the research results of a team of Israeli scientists at the Weizmann Science Institute in Rehovot (Israel) following their investigations into a more effective method of reprogramming adult stem cells into iPS cells. By removing a protein known as Mbd3, the scientists almost achieved a 100% success rate in reprogramming adult stem cells into induced pluripotent stem cells (iPS) (compared to a 10% reprogramming rate documented to date). Furthermore, this method allows cells to be reprogrammed in just one week compared to several months.
Although the study was carried out using adult murine skin cells, scientists estimate that the technique could significantly increase the capacity for reprogramming human adult cells.
Konrad Hochedlinger, a stem cell specialist at Harvard Medical School in Boston (Massachusetts) pointed out that: "This is the first report to show previously unprecedented effective reprogramming".