First birth using an autograft of ovarian tissue collected prior to puberty

Publié le 11 Jun, 2015

An anonymous young woman of 27 has become the first female in the world to give birth to a baby after having had her fertility restored via transplantation of her own ovarian tissues, collected and frozen prior to puberty.  The news was announced by a medical team in Brussels.  The woman gave birth to a healthy baby boy in November 2014.


The patient suffered from a serious genetic blood disorder which was diagnosed before the age of 5.  Her condition was treated with a bone marrow from her brother.  This procedure required chronic treatment in advance (chemotherapy or radiotherapy) likely to destroy ovarian function.  Thus when the patient was 13 years and 11 months old, the doctors removed her right ovary and froze the fragments.


When she wanted to start a family, doctors thawed some of the ovarian tissues and reimplanted the fragments in the left ovary, left in place but not functioning, and in other areas of her body. The grafted tissues started to produce mature oocytes after five months and she became pregnant naturally.


This is the first time that a pregnancy has occurred and resulted in the birth of a child following restoration of a woman’s hormone functions thanks to ovarian tissue autograft.



 Le Monde (Moina Fauchier-Delavigne, Paul Benkimoun) 11/06/2015

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