[Discovery] Non-embryonic stem cells to regenerate bladder tissues

Publié le : 28 March 2014

 A discovery by the UC Davis Institute for Regenerative Cures (University of California) has just been published in the Stem Cells Translational Medicine journal. It highlights the work of a team of scientists who, for the first time, compiled a protocol using non-embryonic stem cells to regenerate damaged bladder tissues.

The final stage would be to replace patients’ damaged bladder tissues, mainly in children suffering from spina bifida (a serious deformity causing paralysis to the legs and incontinence) and adults with bladder cancer. 90% of patients requiring a bladder replacement are adults suffering from bladder cancer.

In order to develop the bladder cells, Professor Kurzrock and colleagues investigated two types of human stem cells. Initial research focused on embryonic stem cells. They opted for non-embryonic cells, namely IPS stem cells derived from skin cells and umbilical blood cells because these types of cell present less of a risk in terms of transplant rejection.

Scientists must carry out another study to prove that IPS cells are safer. This discovery paves the way for other strategies involving IPS cells.

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