Advanced paternal age associated with the risk of schizophrenia in children

Publié le : 8 April 2019

A Chinese study published in the journal Biological Psychiatry links advanced paternal age with the risk of schizophrenia in children. “After taking into account polygenic parental risk scores, each additional decade of fathers’ lives increased the risk of early-onset schizophrenia [1] in children by about 30%,” explained Shi-Heng Wang, the lead author. The explanation for this is apparently “an accumulation of genetic mutations” with age. In contrast, the study concluded that the mother’s age is not associated with the same risk.


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[1] Appearing before the age of 18

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