STEM CELLS

Stem cells are generally characterised by the fact that they can be multiplied identically and  indefinitely, that they can give rise to a prolific amount of transition cells, originally from very different specific cells (nervous, muscular,  …).

Human embryonic stem cells

The preparation of human embryonic stem cells (ES, Embryo Stem Cells) involves the production of a human embryo and/or the use of surplus embryos from an IVF; a sample is taken from a premature embryo (at the blastocyst stage) which requires destroying the embryo. These embryonic stem cells are then cultivated in order to produce a very large quantity of identical cells. 

These cells mark the beginning of  the preparation of specific cells obtained by techniques that are still being fine tuned. These facts have shaken up the scientific, commercial and media worlds in allowing people to think that certain cloning techniques promise long-sought cures for terminally ill patients.   The information has, above all, shaken up the political world, in particular in the UK, Japan, Australia and the USA where there is huge pressure for federal funds to be used for human embryonic research.
The french law of 8th July 2004 recalls that "research on human embryo is forbidden", but authorizes it "exceptionally", for a 5-year time period, on surplus embryos without any parental project.

Adult Stem Cells

Studies on adult stem cells (ASC) have shown that  stem cells were present in many adult tissues but that they were considered not to be as versatile as the embryonic ones as they were  unable to develop into any type of cell.  

However, over the last few years multipotent (pluripotent) stem cells have been found in bone marrow (HSC), in nerve tissue (NSC)  and other organs including blood from the umbilical cord.
Thus it is possible, for example,  to reconstitute all of the blood stem cells from bone marrow stem cells.   
In the same way, nerve stem cells can develop into brain cells or muscle stem cells.  In this way, adult stem cells can have characteristics similar to embryonic ones  (and have the advantage of not being so difficult to obtain); it is foreseeable that adult stem cells could provide effective treatments for numerous patients.
Pedagogical notes
Simple facts about stem cells

Science, Ethics and Politics of Stem Cell and Cloning Research (feb. 2003) after Pr David Prentice (Department of Life Sciences, Indiana State University, USA)
Update 2004 - Adult Stem Cells Addendum
Update 2006 - Current Science of Regenerative Medicine with Stem Cells, David A. Prentice, Journal og Investigative Medicine, January 2006

Vidéo clip embryonnic stem cells by CNN.com

Genetic medicine: the case of embryonic stem cells

Dossiers
Embryo and embryonic research
Cloning
Revision of bioethics laws
Web site
www.stemcellresearch.org
Official Texts
Opinions
European Group on Ethics in Science and New Technologies
Opinion n°16 on Ethical aspects of patenting inventions involving human stem cells, 07/05/2002
Opinion n°15 on Ethical aspects of human stem cell research and use, 14/11/2000
National Consultative Ethics Committee
  Opinion n°67 on the preliminary draft revision of the laws on bioethics, 18/01/2001
Opinion n°53 on the establishment of collections of human embryo cells and their use for therapeutic or scientific purposes.11/03/1997
Report & Declaration
Report on human embryonic stem cell research - commission staff working paper, Commision of the european communities, 3 april 2003

Report of the International Bioethics Committee “The Use of Embryonic Stem Cells In Therapeutic Research", Paris – UNESCO, 6 April 2001

Declaration on the production and the scientific and therapeutic use of human embryonic stem cells, Pontifical Academy for Life, August 25, 2000

Genethique Letters speak about ...

The highly controversial importing of embryos..., n°37

Production of ovocytes from embryonic cells, n°41

Hope for the use of adult cells in the treatment myopathy, n°41

To understand the stakes : a few definitions, n°48

Promising results for research into adult stem cells, n°49

Embryonic stem cells : Reversal of opinion by scientists, n°50

Importing of embryonic stem cells, n°58

Neurones from human stem cells ?, n°58

Umbilical cord blood stem cells : A means of avoiding the ethical and clinical dilemma, n°60

Embryonic stem cells : not as therapeutic as promised..., n°61

France: acceleration of research on embryonic stem cells, n°63

Is adipose tissue a reservoir of stem cells?, n°65

Umbilical cord stem cells: reality and promises, n°69

Ethical embryonic stem cells, n°70

Ethical focus on the 2005 edition of the Telethon,n°71

Taking stock of regenerative therapies using stem cells in 2006, n°77
Stem cells: the alternative solution to umbilical cord blood, n°79
Rome Convention: the therapeutic efficiency of adult stem cells, n°81
Embryonic cell lines without killing the embryo: ethics or intox?, n°81
Stem cells identified in amniotic liquid, n°85
Europe regulates the therapies of the future : which ethics ?, n°88
Human-animal hybrid embryos in Great Britain soon ?, n°88
Europe regulates the therapies of the future : which ethics ?, n°89
Cord blood cells help Type I diabetes, n°90
Pluripotent cells from adult stem cells, n°90
Promises of umbilical cord blood and blockages in France, n°91
Agency of biomedicine: 2006 annual report – Balance of activities, n°94
Research on embryo: French actuality, n°95
Major scientific advances in research on adult stem cells, n°96
Reprogramming adult stem cells, n°97
United Kingdom: decriminalisation of man-animal hybrid embryos, n°103
Use Press Review to consult articles written on this matter