CLONING

Definition :  reproductive or therapeutic cloning ?

Embryo
From fertilization to death, the life of a human being continually evolves and passes through various stages : embryo, foetus, newborn, child, etc. The uninterrupted transition from one stage to another takes place completely naturally and  thus the person is unaware of any change.
The embryo is therefore a human being which begins to develop from the moment fertilisation takes place.
There is no pre-embryonic stage because the human being is unable to exist until the two gametes (reproductive cells) have combined.
It is the fusion of the two cells that marks the beginning of the development of a new human being.

Cloning
There are various sorts of cloning : cellular and embryonic cloning. Cellular cloning is not usually called as such. It concerns the cultivation of simple different cells as used for skin grafts in serious burn cases. This does not cause any ethical problems.

 

Embryonic Cloning
There are two principal methods :
- By splitting the fertilized egg, resulting in several twins that are genetically identical. This technique has been used recently on the monkey Tetra. The technique has also been used on a human being by Hall and Stillman as early as 1993 without any prior consent from an ethics committee and with no  further implantation.

- By introducing the core of a differentiated cell in an enucleated ovule, thus creating a totipotent cell which is capable of multiplying in the same way as an embryo, just like the Dolly case. Thus whatever the age, a donor can have identical twins of different ages.

Reproductive Cloning
The aim of embryonic cloning is to create an identical clone to the donor but of a different age, commonly known as reproductive cloning (such as Dolly) or to produce stem cells (totipotent) which are perfectly compatible with the donor in order to carry out skin grafts, commonly known as non-reproductive cloning or therapeutic cloning.
To say that therapeutic cloning is not reproductive is not true since in both cases a donor’s ovule is used and an embryo is created; the only difference concerns the adaptation of the embryo.

Therapeutic cloning is actually an interrupted form of reproductive cloning.  If it is accepted by the CCNE (National Ethics Consulting Committee)  and the Council of State, and thereafter passed by law, allowing the manufacture of cells or of replacement organs, therapeutic cloning rests upon the principal that a human being can be produced in order to be used as raw material for another human being. Can one really cure at any cost… at the cost of ‘human life’?

An honest reflection on cloning is thus not to talk about ‘therapeutic and reproductive cloning’, since the very principal of cloning is to ‘reproduce’ an embryo, but to question the complete obsession of reproducing something identical and rejecting an alternative.
What is cloning ?

Reproductive Cloning

Reproductive cloning known as therapeutic cloning
Cloning and Legislation

Dossiers

Science, Ethics and Politics of Stem Cell and Cloning Research (feb. 2003) after Pr David Prentice (Department of Life Sciences, Indiana State University, USA)
Update 2004 - Adult Stem Cells Addendum
Update 2006 - Current Science of Regenerative Medicine with Stem Cells, David A. Prentice, Journal og Investigative Medicine, January 2006

Embryo and embryonic research
Stem Cells

Official Texts

Council of Europe
Additional Protocol to the Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine, on the Prohibition of Cloning Human Beings, Council of Europe, 12/01/98

European Group on Ethics

EGE Opinion n°9 on Ethical aspects of cloning techniques, 28/05/1997

National Consultative Ethics Committee Opinions

N°67 Opinion on the preliminary draft revision of the laws on bioethics 18/01/01
N°54 Opinion : Reply to the President of the French Republic on the subject of reproductive cloning, 22/04/1997
United Nations
Ad Hoc Committee on an International Convention against the Reproductive Cloning of Human Beings
Unesco
Human Cloning - Ethical issues, 2005
Genethique Letters speak about ...

Against cloning : The Franco-German game at the UN..., n°37

Nature defeats cloning of primates, n°40

Therapeutic cloning : the European Parliament says "no", n°40

No prohibition of human cloning by the UNO, n°47

To understand the stakes : a few definitions, n°48

Korea : Human embryos obtained by cloning ?, n°50

The birth of a mouse by parthenogenesis?, n°52

United Kingdom authorises cloning of human embryos, n°57

Cloning at the UN, n°58

Cloning banned by the UN : Defeat for the convention, n°60

UN pronounced itself against any king of human cloning, n°63

Resolution of European Parliament against oocyte trafficking and cloning, n°53

France: Bill on therapeutic cloning, n°66

Ethical focus on the 2005 edition of the Telethon, n°71

The human cloning scandal in South Korea : toward a post-cloning era, n°72

Claeys’ report asks for legalisation of cloning, n°76
Europe: vote against the funding for research on embryos and cloning, n°77
Ferry’s report: authorising “scientific” cloning?, n°81
Fagniez report recommends legalization of research cloning, n°81
Claeys’ report asks for legalisation of scientific cloning, n°85
Human-animal hybrid embryos in Great Britain soon ?, n°88
Towards the creation of “man-animal” hybrid embryos? n°93
Major scientific advances in research on adult stem cells, n°96
United Kingdom: decriminalisation of man-animal hybrid embryos, n°103
Use Press Review to consult articles written on this matter